New Tools and Technology

i. Vector Control Tools

1.    Bacillus thuringiensis var. israelensis (VCRC B17) and B. sphaericus (VCRC B42)  – mosquito larvicidal agents.

2.    B. subtilis subsp. subtilis (VCRC B471) and Pseudomonas flourescens (VCRC B426) – mosquito pupicidal agents.

3.    Romanomermis iyengari – a mosquito killing nematode.

4.    DEPA – a synthetic mosquito repellent.

5.    DPE-28 – a mosquito growth regulator.


ii. Macrofilaricides

1.    Macrofilaricidal agent from the fruit extract of Trachyspermum ammi against adult filarial worms

2.    Napthoquinone analogues with macrofilaricidal activity against adult filarial worms


iii. Diagnostics

1.    An RT-PCR assay for diagnosis of infective (L3) stage larvae of Wuchereria bancrofti.

2.    Molecular diagnostics for insect vectors.


iv. By-products of medical importance

1.    Cyclosporine A, an immunosuppressive agent from a mosquitocidal fungus, Tolypocladium sp. (VCRC F 21).

2.    Thrombinase, a blood clot dissolving enzyme from the mosquito larvicidal B. sphaericus (VCRC B42).

3.    L-DOPA, a drug for Parkinson’s disease from the mosquito larvicidal mutant of B. thuringiensis var. israelensis (VCRC B17).

A metabolite, effective against multi drug resistant microbes from a mosquito pupicidal bacterium, B. amyloliquefaciens (VCRC B483).


v. By-products of commercial value

1.    Dehairing enzyme from the mosquito larvicidal agent, B. thuringiensis var. israelensis (VCRC B17).



Last Updated on : 21/11/2016