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VCRC has been carrying out Basic & Applied research with the primary objective of finding newer methods and developing strategies for the control of vector borne-diseases. The World Health Organization (WHO) has designated the VCRC as a collaborating Centre for Research and Trainining in Lymphatic Filariasis and Integrated Methods of Vector Control.
Products Developed
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DEPA - a synthetic insect repellent
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Cyclosporin A - an immunosuppresive agent licensed to M/S Nixcil Pharmaceuticals & Specialities Ltd. Lucknow
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Thrombinase - a blood clot dissolving enzyme for treating strokes/myocardial infarctions, licenced to M/S Malladi Research Centre, Chennai
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Sperifix - a controlled release formulation of Bacillus sphaericus for mosquito larval control, assigned to NRDC
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Deltafix - a controlled release formulation of Bacillus thuringiensis var. israelensis for mosquito larval control, assigned to NRDC
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a mosquito oviposition attractant assigned to NRDC
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B426 - a mosquito pupicide assigned to NRDC
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Controlled release formulation of DPE-28 an IGR for mosquito larval control assigned to NRDC
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IIFT - an insecticide impregnated fabric trap for sampling filariasis vector
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L - DOPA - a drug for Parkinson's disease.
Patents Obtained
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A mosquito larvicidal preparation of Bacillus thuringiensis var israelensis Indian Patent Appl. No. 4.22.1.1/94055(Dr.K. Balaraman, Dr. S.L.Hoti, Dr. A.M. Manonmani)
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A Process for the preparation and formulation of of a mosquito larvicide from Bacillus sphaericus, Indian Patent Appl.No. 4.22.1.2/94056
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A process for the production of CYCLOSPORIN A, an immunosuppresent from Tolypocladium sp. Indian Patent.no. 182916 dt. 19-9-94; European Patent EP-725-076 01.02.95-95 EP-300674 (07.08.96); US Patent No. 5,656,459 dt. 12.8.1997(Dr.K. Balaraman, Dr. Nisha Mathew)
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A process for the production of THROMBINASE, a blood clot dissolving enzyme from Bacillus sp. Indian Patent Appl.no 232/DEL/91 dt 21-3-91; US patent no. 5434059 dt 18-7-95; European patent no. 0624642 dt. 20.1.1999(Dr.K. Balaraman, Dr. Kuppuswamy)
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A process for the preparation of CYCLOSPORIN A an immunosuppresent from Tolypocladium sp. Canadian Patent No. 2,142,240 (2003)
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Process for the preparation of a controlled release agent for controlling growth of the insecticides. Indian Patent No. 191820 dt. 11.01.2005. Dr. Nisha Mathew,Dr. M. Kalyanasundaram & Dr. K . Balaraman.
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F24 - A process for the production of mosquito pupicidal compound. Indian Patent no.199635 dt.22.9.2006(Dr.K. Balaraman, Ms. I. geetha, Mr. G. Prabakaran, Mr. V. Padmanabhan, Dr. K.P. paily & Dr. S.L. Hoti)
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B426 - A process for the production of mosquito oviposition attractant. Indian Patent no.192872 dt.7.4.2006(Dr.K. Balaraman, Ms. I. geetha, Mr. G. Prabakaran, Mr. V. Padmanabhan & Dr. K.P. paily)
Patents Filed
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Macrofiaricidal activity of monoterpene derivatives having phenolic characteristics from the fruit extract of Trachyspermum ammi against filairasis. Indian Patent Application No.1082/DEL/2003
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Novel macrofilaricidal composition and process for preparing the same. Indian Patent Appl.No.1083/DEL/2003
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Microbial fermentation process from bird feather for the production of bio-pesticides Indian Patent Appl.No.319/Del/2005
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Lethal mosquito attractant and preparation thereof Indian Patent Appl.No.358/Del/2006
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28. New bacterial culture medium for the production of mosquito pathogenic bacillus using industrial wastesIndian Patent Appl.No.1106/Del/2008.
Diagnostics/kits under development
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Monoclonal antibody based ELISA for the diagnosis of lymphatic filariasis
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RT-PCR assay for the detection of infectivity with filarial parasites in vectors
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rDNA-ITS2 region based probes developed for two sibling species of Anopheles fluviatilis, a major vector of malaria in hilly and forest areas.
Control strategies developed for
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Malaria in coastal areas of Pondicherry
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Bancroftian filariasis in Pondicherry
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Urban malaria in Salem, Tamil Nadu
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Coastal malaria in Rameswaram Island, Tamil Nadu
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Malaria in riverine areas in Sathanur, Tamil Nadu
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Brugian filariasis in Shertallai, Kerala
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Tribal malaria in Koraput, Orissa
Strategy Development
Decision Support tools
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Development of mathematical models (LYMPHASIM and EPIFIL) to optimize appropriate control strategies
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Rapid assessment procedures for infection / disease
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Rapid epidemiological mapping of bancroftian filariasis endemic areas
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Filariasis risk mapping using geostatistical and GIS tools
Epidemiological studies
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Socio-economic burden of filariais and malaria
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Dynamics of transmission, infection and disease, filariasis and malaria
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Epidemiological investigations of vector-borne disease outbreaks
Clinical studies
Master plans for mosquito control
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Township, Neyveli Lignite Corporation, Tamil Nadu
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Muncipal Corporation, Kochi, Kerala,
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Muncipal Corporation, Bangalore, Karnataka
Last Updated on : 01/04/2014
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